Technical Data

C2548-85H
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E IHC
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-CD155 (Poliovirus Receptor, Nectin-like Protein 5, NECL-5, PVR, PVS)

The poliovirus receptor (PVR) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. PVR is involved in intercellular adhesion and its cytoplasmic domain may target endocytic vesicles to the microtubular network. The extracellular domain of PVR mediates cell attachment to the extracellular matrix molecule vitronectin, while its cytoplasmic domain interacts with the dynein light chain Tctex-1. PVR is a primate-restricted protein expressed during development in mesenchymal tissues and ventrally derived structures within the CNS. Its exact biological function remains to be determined; it is reported that PVR is aberrantly expressed in tumors of neuroectodermal origin.

Applications
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:1000 Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa403-417 of human PVR (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PVR.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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