Chromatin Assembly Factor 1, p60 (CAF-1 p60)

C5069-94A

Clone Type

Monoclonal

Host

Mouse

Source

Human

Isotype

IgG1

Clone Number

SS 24 1-68

Grade

Ascites

Applications

Crossreactivity

Shipping Temp

Blue Ice

Storage Temp

-20°C

Mouse Anti-Chromatin Assembly Factor 1, p60 (CAF-1 p60)

Chromatin assembly factor 1 (CAF-1) is a member of the histone chaperone family. It is required for inheritance of epigenetically determined chromosomal states, and in vitro, it promotes the assembly of chromatin during DNA replication and DNA repair. CAF-1 is a complex of three subunits; p150, p60, and p48. This complex is localized to the nucleus of human cells. Both the composition and the biochemical activity of CAF-1 are conserved among human, yeast and Drosophila.

Immunoprecipitation (0.1-1 ug). This antibody does not work for Western Blot.

Immunogen

Recombinant human CAF-1p60

Form

Supplied as ascites, 0.09% sodium azide.

Purity

Ascities

Specificity

Recognizes human CAF-1p60.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

General References:|1. Smith, S., et al. Immunological Characterization of Chromatin Assembly Factor I, a Human Cell Factor Required for Chromatin Assembly during DNA Replication in Vitro. JBC, 266(18): 12041-12047, 1991. 2. Shibahara, K., et al. Replication-Dependent Marking of DNA by PCNA Facilitates CAF-1-Coupled Inheritance of Chromatin. Cell, 96: 575-585, 1999.

USBio References

No references available

Technical Data