Technical Data

C7906-06A1-PE
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Conjugate
PE
Isotype
IgG
Grade
Affinity Purified
Applications
FLISA IHC WB
Crossreactivity
Bo Hu
Shipping Temp
Blue Ice
Storage Temp
4°C Do Not Freeze
Notes
Preservative Free
Rabbit Anti-CPT1A, CT (Carnitine O-palmitoyltransferase 1, Liver Isoform, CPT1-L, Carnitine O-palmitoyltransferase I, Liver Isoform, CPTI-L, CPT I, Carnitine Palmitoyltransferase 1A, CPT1) (PE)

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.

Applications
Suitable for use in FLISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 606-636 in the C-terminal region of human CPT1A, UniProt Accession #P50416.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity
Purified by Protein A/G affinity chromatography
Specificity
Recognizes human CPT1A. Species Crossreactivity: bovine

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Rasmussen, B.B., et al., J. Clin. Invest. 110(11):1687-1693 (2002). 2. Ogawa, E., et al., J. Hum. Genet. 47(7):342-347 (2002). 3. Cook, G.A., et al., Am. J. Med. Sci. 318(1):43-48 (1999). 4. IJlst, L., et al., J. Clin. Invest. 102(3):527-531 (1998). 5. Britton, C.H., et al., Genomics 40(1):209-211 (1997).
USBio References
No references available
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