Technical Data

C8450-25A
Clone Type
Polyclonal
Host
Rabbit
Isotype
IgG
Grade
Serum
Applications
E
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Cyclic GMP (cGMP) (Not for Export EU)

Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution
ELISA: 1:4000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Also Available
C8450-25A: Cyclic GMP (cGMP) Pab Rb x C8450-25B: Cyclic GMP (cGMP) Pab Rb x C8450-25C: Cyclic GMP (cGMP) Pab Rb x
Immunogen
Cyclic GMP (cGMP)
Form
Supplied as a liquid in PBS, 0.09% sodium azide
Purity
Serum
Specificity
Recognizes cGMP

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
No references available
USBio References
No references available
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