Rabbit Anti-DCD, CT (Dermcidin, Preproteolysin, Survival-promoting Peptide, DCD-1, DSEP, AIDD)
DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
Applications
Suitable for use in Immunohistochemistry, Western Blot and Indirect Flow Cytometry. Other applications not tested.
Recommended Dilutions
Immunohistochemistry (FFPE): 1:50-1:100 Western Blot: 1:1000 Indirect Flow Cytometry: 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids aa74-103 in the C-terminal region of human DCD, UniProt Accession #NP_444513 |Cellular Localization: Secreted
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human DCD.
