Technical Data

D3714-20A
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000784.2
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-DIO2, ID (Type II iodothyronine deiodinase, Type-II 5'-deiodinase, Type 2 DI, DIOII, 5DII, TXDI2, ITDI2, DIO2)

DIO2 belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3).

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-1:500 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the Center region of human DIO2 (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human DIO2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. He,B.,et.al., Prog. Neuropsychopharmacol. Biol. Psychiatry 33(6), 986-990 (2009). 2. Heemstra,K.A., et.al., J. Clin. Endocrinol. Metab. 94(6), 2144-2150 (2009).
USBio References
No references available
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