Technical Data

D9904-50D
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E
Crossreactivity
Hu
Accession #
NP_054883.3, NP_659003.1, NP_001158077.1
Gene ID
53827
Shipping Temp
Blue Ice
Storage Temp
-20°C
Goat Anti-Dysadherin (FXYD Domain-containing Ion Transport Regulator 5, FXYD5, DYSAD, IWU1, HSPC113, UNQ2561/PRO6241)

This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution
ELISA: 1:8000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to GKCRQLSRLCRNHCR, from human Dysadherin, at C-terminal (NP_054883.3, NP_659003.1, NP_001158077.1).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Dysadherin.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Arystarkhova E, Donnet C, Muñoz-Matta A, Specht SC, Sweadner KJ. Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma-subunit in response to stress. Am J Physiol Cell Physiol. 2007 Mar;292(3):C1179-91.
USBio References
No references available
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