Technical Data

E2249-81
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_060725
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-ELP2, CT (Elongator Complex Protein 2, ELP2, Stat 3-interacting Protein 1, StIP1, SHINC-2, STATIP1)

ELP2 regulates the ligand-dependent activation of STAT3. The protein acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the C-terminal region of human ELP2 (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human ELP2.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Kim,J.H., Proc. Natl. Acad. Sci. USA 99(3), 1241-1246 (2002). 2. Hawkes,N.A., J. Biol. Chem. 277(4), 3047-3052 (2002).
USBio References
No references available
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