Rabbit Anti-Exportin-4 (Exp4, XPO4, KIAA1721)
Nuclear transport receptors of karyopherin:importin-beta superfamily mediate various transport pathways between nucleus and cytoplasm. Exportin-4 is a novel mammalian member of this family. It is a RanGTP-binding protein consisting of N-terminal RanGTP-binding motif. It functions as a nuclear export receptor for eIF-5A and also might function as an export adapter in RNA export. It is also involved in nuclear export of Smad3 and regulation of Smad signaling.
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1-3ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Jurkat cell lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa850-950 of human Exportin-4.
Form
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Purity
Purified by Protein G affinity Chromatography.
Specificity
Recognizes human Exportin-4. Species Crossreactivity: chicken, chimpanzee, canine, mouse, rat, rhesus monkey. Species sequence homology: bovine, xenopus, zebrafish.
