Technical Data

F6002-73
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mk Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-Formin-like Protein 2 (FMNL2, Formin Homology 2 Domain-containing Protein 2, FHOD2, FLJ37546, KIAA1902)
Formin-like 2

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.

Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1-3ug/ml Immunohistochemistry (paraffin): 5-10ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Whole mouse embryo body tissue lysate
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa1-50 of human Formin-like protein 2.
Form
Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Formin-like protein 2. Species Crossreactivity: chimpanzee, monkey, rat. Species sequence homology: mouse, bovine.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Katoh, M. et al. Int. J. Oncol. 22:1161-1168 (2003).
USBio References
No references available
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