Goat Anti-Fructose-2,6-Biphosphatase 2 (PFKFB2, 6-phosphofructo-2-kinase)
fructose-2,6-bisphosphatase, cardiac isozyme, PFKFB, cardiac, OTTHUMP00000034286, OTTHUMP00000034285, 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2, PFK-2/FBPase-2, MGC138310, MGC138308, DKFZp781D2217, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, PFKFB2
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
Applications
Suitable for use in ELISA. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:16,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to SEQNNNSYETKTP-C, from the N-terminus of human Fructose-2,6-Biphosphatase 2 (NP_006203.2; NP_001018063.1).
Form
Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by peptide affinity chromatography.
Specificity
Recognizes Fructose-2,6-Biphosphatase 2. Species sequence homology: human, canine, bovine.
