Rabbit Anti-Glicentin (Glucagon) (Not for Export EU)
Glicentin contains the glucagon sequence and is produced in a prominent population of endocrine cells in the distal intestine as well as in pancreatic glucagon cells and in the nerves in the brain. Serum levels of glicentin are elevated after food uptake and in certain clinical conditions, e.g. after resections of the intestine. The functional role of glicentin is largely unknown. Glicentin occurs in endocrine tumors arising in the distal intestine (rectal carcinoids) and in pancreatic islet cell tumors.
Applications
Suitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended Dilution
Immunohistochemistry (frozen and paraffin): 1:50 dilute immediately before use with PBS. (No protease pre-treatment required.). Optimal dilution determined by the researcher.
Positive Control
Pancreas, small intestine.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Porcine pancreatic glucagon conjugated to BSA
Form
Supplied as a liquid, 0.09% sodium azide.
Specificity
Recognizes Porcine glycentin as well as glucagon. The antibody can be used for the diagnosis of tumors from the distal intestine (rectal carcinoids) as well as pancreatic islet cell tumors. Species Crossreactivity: Human and rat.
