G4005-96E

Rabbit Anti-Grik3 (EAA5, Excitatory amino acid receptor 5, GLR7, GluR7, GLUR7, GluR-7, GluR7a, Glutamate receptor, ionotropic kainate 3 precursor, Glutamate receptor 7)

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes (1). Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels (2,3). Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation (4). Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia (5,6). This Grik3 antibody does not cross-react with Grik2.