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G8972-15 Mouse Anti-GRK 4-6

Specifications
References
Clone Type
Monoclonal
Host
Mouse
Source
Bovine
Swiss Prot
P32298
Isotype
IgG1,k
Clone Number
A16/17
Grade
Purified
Applications
E IP WB
Crossreactivity
Bo Hu Mo Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.

Applications
Suitable for use in ELISA, Western Blot and Immunoprecipitation. Other applications not tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
GST fusion protein corresponding to residues 463-590 of bovine GRK 5.
Form
Supplied as liquid in 0.1M Tris-glycine, pH 7.0, 0.05% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Recognizes GRK 4, GRK 5 and GRK 6. Species Crossreactivity: Human, mouse and rat.
References
General Freedman, N.J., et al., J. Biol. Chem. 272: 17734-11743, 1997. Pitcher, J.A., et al., J. Biol. Chem. 271: 24907-24913, 1996. Nagayama, Y., et al., J. Biol. Chem. 271: 10143-10148, 1996. Application Oppermann, M., et al., Proc. Natl. Acad. Sci. USA 93: 7649-7654, 1996.
USBio References
No references available
Conjugates
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