Technical Data

I7502-77
Clone Type
Monoclonal
Host
Mouse
Source
Human
Isotype
IgG1,k
Clone Number
17G10.2
Grade
Affinity Purified
Applications
FC
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C
Notes
Preservative Free
Mouse Anti-ILT7 (Leukocyte Immunoglobulin-like Receptor Subfamily A Member 4, CD85 Antigen-like Family Member G, Immunoglobulin-like Transcript 7, ILT-7, CD85g, LILRA4)

ILT7 (immunoglobulin-like transcript 7) is a member of leukocyte immunoglobulin-like receptor (LIR or LILR) gene family, also known as CD85g and LILRA4. It contains four extracellular Ig domains. In association with FceR1y, ILT7 forms a receptor complex that transduces ITAM-mediated signals. ILT7 is specifically expressed on plasmacytoid dendritic cells (pDCs), but not on myeloid dendritic cells and other peripheral blood leukocytes. ILT7 negatively regulates the innate immune functions of human pDCs. Cross-linking I7502-77 antibody is able to trigger ILT7 mediated signaling.

Applications
Suitable for use in Flow Cytometry. Other applications not tested.
Recommended Dilution
Flow Cytometry: ≤0.5ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added.
Purity
Purified by affinity chromatography. Endotoxin: <0.1EU/ug (LAL)
Specificity
Recognizes human ILT7.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Cao, W., et al. 2006. J. Exp. Med. 203(6):1399. 2. Brown, D., et al. 2004. Tissue Antigen. 64:215. 3. Rissoan, MC., et al. 2002. Blood. 100:3295.
USBio References
No references available
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