I7661-99
Clone Type
MonoclonalHost
MouseSource
HumanIsotype
IgG1Clone Number
5C55Grade
Highly PurifiedApplications
E NCrossreactivity
HuShipping Temp
Blue IceStorage Temp
-20°CMouse Anti-Interferon alpha (IFNa)
Interferons (IFNs) appear early after viral infection locally and systematically to limit spread of viral infection. They also affect cell differentiation, growth, surface antigen expression and immunoregulation. There are three naturally occurring interferons: alpha, beta and gamma. Interferon alpha (IFN-alpha, IFNa) is also known as leukocyte interferon. B-lymphocytes are the predominant cellular producers of INF-alpha. IFN-alpha is derived from lymphoblastic tissue. IFN-alpha comprises a family of related, homologous proteins, each exhibiting a unique activity profile. The activities of the different IFN-alpha species on viruses can vary twenty fold or more. INF-alpha has a number of therapeutic applications in the treatment of various human cancers and diseases of viral origin.
Applications
Suitable for use in Direct ELISA and Neutralization. Not suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilution
Direct ELISA: 1:10,000 dilution will yield 0.5 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Recombinant human Interferon alpha.
Form
Supplied as a liquid in PBS.
Purity
Purified by ion exchange chromatography.
Specificity
Recognizes human Interferon alpha.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1 Miller JD, Pegelow DF, Dempsey JA, J Physiol 2005 Jan 13; 2. Deheyn DD, Gendreau P, Latz MI, Mar Environ Res 2005 Jul;60(1):1-33 3. . Sosnowski M, Clark E, Macfarlane PW, Ann Noninvasive Electrocardiol 2005 Jan;10(1):7-15 4.. Zinkstok RT, Witte S, Eikema KS, Opt Lett 2005 Jan 1;30(1):78-80 5. Passively mode-locked 914-nm Nd:YVO4 laser. Schlatter A, Krainer L, Paschotta R, Opt Lett 2005 Jan 1;30(1):44-6 6. Fernandes FC, van Spaendonck RL, IEEE Trans Image Process 2005 Jan;14(1):110-24.USBio References
No references available