Technical Data

I8449-08A
Clone Type
Polyclonal
Host
Rabbit
Source
Rat
Isotype
IgG
Grade
Affinity Purified
Applications
WB
Crossreactivity
Rt
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-IP-10 (interferon-gamma induced protein 10kD, cytokine responsive gene 2, Crg-2, mob-1)

IP-10 (interferon-gamma induced protein 10kD; in mouse, also called cytokine responsive gene 2, Crg- 2, or mob-1) is a highly inducible, primary response gene that belongs to the CXC chemokine superfamily. It was first cloned in 19851. The biological functions of IP-10 are still unclear. Like Mig, IP-10 has no activity on neutrophils. Its functions include stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Mig and IP-10 share the same receptor, CXCR3 (2,3).

Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 1:5000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
E. coli expressed rat IP-10
Form
Supplied as a liquid, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes rat IP-10

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Luster, A.D., et al. (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 315(6021):672-676 2. Neville, L.F., et al. (1997) The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cytokine Growth Factor Rev 8(3):207-219 3. Farber, J.M. (1997) Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol. 61:246-257
USBio References
No references available
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