Technical Data

K0138-03
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_000209.2; NP_861463.1
Gene ID
3784
Shipping Temp
Blue Ice
Storage Temp
-20°C
Goat Anti-Kv7.1 (KCNQ1, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 1, IKs Producing Slow Voltage-gated Potassium Channel Subunit alpha KvLQT1, KQT-like 1, Voltage-gated Potassium Channel Subunit Kv7.1, Kidney and Cardiac Voltage Dependend K+ Channel, Potassium Voltage-gated Channel, KQT-like Subfamily, Member 1, Slow Delayed Rectifier Channel Subunit)

This gene encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA:1:8000 Western Blot:1-3ug/ml Optimal dilutions to be determined by the researcher.
Positive Control
Human Heart lysates
Control Peptide
K0138-03-P: Kv7.1
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic peptide corresponding to C-EQLTVPRRGPDEGS, from the C-Terminus of human KCNQ1. Species sequence homology: bovine, mouse, rat and canine
Form
Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Kv7.1 at ~60kD.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet. 2008 Aug 17.
USBio References
No references available
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