Lck Interacting Molecule is a new raft-associated adaptor protein involved in regulation of T cell activation by coreceptors. Lck Interacting Molecule becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-Lck Interacting Molecule associates with the Src family kinase Lck and its negative regulator, Csk. Ectopic expression of Lck Interacting Molecule in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.