Goat Anti-MYRIP, CT (Rab Effector MyRIP, Exophilin-8, Myosin-VIIa- and Rab-interacting Protein, Slp Homolog Lacking C2 Domains c, SlaC2-c, SLAC2C)
A molecular complex composed of Rab27A, MYRIP and myosin VIIa bridges retinal melanosomes to the actin cytoskeleton and thereby mediates the local trafficking of these organelles. The defect of this molecular complex is likely to account for the perinuclear mislocalization of the melanosomes observed in the retinal pigment epithelium cells of myosin VIIa-defective mice.
Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:64,000 Western Blot: 1:64,000 & 0.1-0.3ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-KDLMEPALESAVMY of human MYRIP at C-terminal.
Form
Supplied as a liquid in Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.||
Specificity
Recognizes human MYRIP.
