Rabbit Anti-NALP8, NT (NACHT, LRR and PYD Domains-containing Protein 8, Nucleotide-binding Oligomerization Domain Protein 16, PYRIN and NACHT-containing Protein 4, NLRP8, NOD16, PAN4)
NALP8, like other NALP proteins, is a cytoplasmic protein that forms a subfamily within the larger CATERPILLER protein family. NALP8 is a short NALP, with an N-terminal pyrin (MEFV) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. Though the exact function of NALP8 is yet unknown reports suggest that it may be involved in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes.
Applications
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1-2ug/ml Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to 16aa from human NALP8 at N-terminus.
Form
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human NLRP8.
