Technical Data

P1003-08A
Clone Type
Polyclonal
Host
Guinea pig
Source
Rat
Isotype
IgG
Grade
Serum
Applications
IC IHC
Crossreactivity
Rt
Gene ID
5024
Shipping Temp
Blue Ice
Storage Temp
-20°C
Guinea pig Anti-P2X3 Receptor (Not for Export EU)

P2X3 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from rat dorsal root ganglia. P2X3 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X3 is expressed in nociceptive sensory neurons.

Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 1:100-1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa383-397, VEKQSTDSGAYSIGH, from the carboxy-terminus of the rat P2X3 Receptor protein.
Form
Supplied as a liquid, 0.05% sodium azide.
Purity
Serum
Specificity
Recognizes rat P2X3 Receptor. Species Crosseactivity: human and mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Chen, C.C., et al.: A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377:428-431 (1995). 2. Lewis, C., et al.: Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 377: 432-425 (1995). 3. Vulchanova, L., et al.: Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology 36: 1229-1242 (1997).
USBio References
No references available
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