Mouse Anti-PAK3 (p21 Activated Kinase 1, p21(CDKN1A)-activated Kinase 1, PAK-1, Beta PAK, Beta-PAK, bPAK, hPAK1, Mental Retardation X-linked 30, MRX30, MRX47, Oligophrenin 1, OPHN1, Serine/threonine-protein Kinase PAK 1)
Oligophrenin1 stimulates GTP hydrolysis of members of the Rho family. It could activate GTPase targets that are known to affect cell migration and outgrowth of axons and dendrites. It is a 802 amino acid protein of estimated molecular mass of ~92kD that is expressed in the brain. Defects in Oligophrenin1 are the cause of mental retardation X-linked OPHN1-related (MRXSO).
Applications
Suitable for use in Western Blot and ELISA. Other applications have not been tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Partial recombinant human Oligophrenin 1 (641-735) with a GST tag.
Form
Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
Purity
Purified by affinity chromatography.
Specificity
Recognizes human Oligophrenin 1.
