Mouse Anti-Parvovirus B19, Human (Biotin)
Parvovirus B19 infection is common among children and adults and is often asymptomatic. Parvovirus B19 infection can result in serious and occasionally fatal hematologic diseases in susceptible patients, and is the cause of "fifth disease", a highly contagious infection of childhood. In sickle cell disease and other hereditary and acquired hemolytic anemias, acute B19 infection results in transient aplastic crisis, in which hemoglobin levels precipitously fall, anemia becomes life threatening, and congestive heart failure may ensue. Parvovirus B19 can also infect the fetus causing severe anemia, congestive heart failure, and heath in utero or at birth.
Applications
Suitable for use in ELISA, Immunocytochemistry and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Immunohistochemistry: formalin-fixed, paraffin-embedded sections Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
B-19 virus purified from an acute serum specimen from a child with aplastic crisis
Form
Supplied as a liquid in PBS, pH 7.4. No preservative added. Labeled with Biotin.
Specificity
Recognizes human parvovirus B19, amino acids 446-466 of VP2. Antibody inhibits haemagglutination.
