Rabbit Anti-Postsynaptic Density Protein 95 (PSD-95, PSD95, Discs Large Homolog 4, DLG4, Human Post-synaptic Density Protein 95, Synapse-associated Protein 90, SAP90, SAP-90)
Postsynaptic Density protein 95 (PSD95) belongs to the membrane-associated guanylate kinase (MAGUK) family. As a scaffolding protein, PSD95 controls of receptor trafficking during synaptic plasticity by anchoring synaptic proteins. Specifically, PSD95 is necessary in synaptic plasticity associated with NMDA receptor signaling. After hetermultimerization with DLG2, PSD95 associates with cytoplasmic tail of NMDA receptor subunit and potassium channel clusters. PSD95 has been linked to autism, drug addiction, and learning
Applications
Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested.
Recommended Dilutions
Western Blot: 1:1000-1:5000 Immunocytochemistry: 1:100-1:250 Flow Cytometry: 1:20 Immunoprecipitation: 1:10 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Immunogen
A synthetic peptide corresponding to residues in the N-terminus of human PSD95 (P78352).
Form
Supplied as a liquid in PBS, pH 7.4, 0.05% BSA, 0.01% sodium azide, 50% glycerol
Specificity
Recognizes human PSD95. Species Crossreactivity: mouse and rat
