Mouse Anti-POU4F3/Brn-3C (POU Domain Class 4 Transcription Factor 3, Brain-Specific Homeobox/POU Domain Protein 3C, POU4F3, BRN3C)
POU domain class 4 transcription factor 3, Brain-specific homeobox/POU domain protein 3C, POU4F3, BRN3C
Brn-3C may play a role in determining or maintaining the identities of a small subset of visual system neurons. It is expressed in the brain and it seems to be specific to the retina. Defects in Brn-3C are the cause of non-syndromic sensorineural deafness autosomal dominant type 15 (DFNA15) which is a form of sensorineural hearing loss. Sensorineuraldeafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Applications
Suitable for use in Western Blot, Immunofluorescence, Immunohistochemistry and ELISA. Other applications not tested.
Recommended Dilution
Immunohistochemistry: 10ug/ml Optimal dilution determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Partial recombinant human Brn-3C (100-191) with a GST tag.
Form
Supplied as a lyophilized powder in PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
Purity
Purified by Protein G affinity chromatography.
Specificity
Recognizes human POU4F3/Brn-3C.
