Rabbit Anti-POTE, CT (ANKRD26-like Family B Member 3, Ankyrin Repeat Domain-containing Protein 21, Protein POTE, Prostate, Ovary, Testis-expressed Protein, A26B3, ANKRD21, POTE Ankyrin Domain Family Member D)
The POTE protein contains seven ankyrin repeats between amino acids 140 and 380. Expression of POTE in prostate cancer and its undetectable expression in normal essential tissues make POTE a candidate for the immunotherapy of prostate cancer. The existence of a large number of closely related but rapidly diverging members, their location on multiple chromosomes and their limited expression pattern suggest an important role for the POTE gene family in reproductive processes. POTE is expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. It localizes to basal and terminal prostate epithelial cells.
Applications
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Immunohistochemistry (paraffin): 1:10-1:50 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids within aa549~579 in the C-terminal region of human POTE.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human POTE.
