P9109-40J
Clone Type
PolyclonalHost
RabbitSource
HumanIsotype
IgGGrade
PurifiedApplications
E WBCrossreactivity
Hu MoShipping Temp
Blue IceStorage Temp
-20°CRabbit Anti-PTP gamma, ID (Receptor-type Tyrosine-protein Phosphatase gamma, Protein-tyrosine Phosphatase gamma, R-PTP-gamma, PTPRG, PTPG)
PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 1:1000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 751-782 in the central region of human PTP gamma, UniProt Accession # P24370.
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human PTP gamma. Species Crossreactivity: mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1.Liu, S., et al., Breast Cancer Res. Treat. 71(1):21-35 (2002). 2.Kastury, K., et al., Genomics 32(2):225-235 (1996). 3.Barnea, G., et al., Mol. Cell. Biol. 13(3):1497-1506 (1993). 4.LaForgia, S., et al., Proc. Natl. Acad. Sci. USA 88(11):5036-5040 (1991). 5.Krueger, N.X., et al., EMBO J. 9(10):3241-3252 (1990).USBio References
No references available