Goat Anti-PCDH11Y (Protocadherin 11 Y-linked, PCDH11X Protocadherin 11 X-linked)
protocadherin-S, protocadherin X, protocadherin 11X, PCDHX, PCDH11, PCDH-X, RP13-138P15.1, protocadherin Y, protocadherin 22, protocadherin 11 X-linked, OTTHUMP00000033077, PCDHY, PCDH22, PCDH11X, PCDH-PC, protocadherin 11 Y-linked, PCDH11Y
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation.
Applications
Suitable for use in ELISA. Other applications have not been tested.
Recommended Dilutions
Peptide ELISA Titer: 1:8000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-KYNWVTTPTTFK, from the internal region of human PCDH11Y (NP_116753.1; NP_116754.1; NP_116755.1; NP_055337.1; NP_055337.1; NP_116750.1; NP_116751.1).
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity
Purified by peptide affinity chromatography.
Specificity
Recognizes PCDH11Y. Species sequence homology: human. This antibody is expected to recognize all reported Y-linked isoforms (NP_116753.1; NP_116754.1; NP_116755.1) and all reported X-linked isoforms (NP_055337.1; NP_055337.1; NP_116750.1; NP_116751.1).
