Rabbit Anti-Sialoprotein, Bone, aa108-122 (BSP, Bone Sialoprotein 2, BSP2, Cell-binding Sialoprotein, Integrin-binding Sialoprotein) (Not for Export EU)
Bone sialoprotein (BSP) is one of the major noncollagenous proteins in the extracellular matrix of bone. It is a phosphorylated glycoprotein with an approximate molecular weight of 70-80kD. The protein has been found in osteoblasts and osteocytes. BSP is synthesized and secreted by bone-, dentin- and cementum-forming cells. Diseases concerning the bone turnover, pathological bone alterations as well as the rapid increase of osteoporosis make it necessary to establish new markers. Bone sialoprotein is discussed as a potential serum marker for monitoring bone remodelling.
Applications
Suitable for use in ELISA, Immuncytochemistry and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1000 Immunocytochemistry: 1:100 Western Blot: 1:250 Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized powder may be stored at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Synthetic human Bone Sialoprotein (aa 108-122) (YTGLAAIQLPKKAGD)
Form
Supplied as a lyophilized powder
Specificity
Recognizes human Bone Sialoprotein (Epitope: aa 108-122)
