Mouse Anti-SLC4A8 (Electroneutral Sodium Bicarbonate Exchanger 1, Electroneutral Na(+)-Driven Cl-HCO3 Exchanger, Solute Carrier Family 4 Member 8, k-NBC3, KIAA0739, NBC, NBC3, NDCBE1) (Azide Free)
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.
Applications
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry (paraffin): 3ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to a portion of amino acids within aa187-287 of human SLC4A8.
Form
Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SLC4A8.
