Rabbit Anti-Spectrin Beta 3 (Beta III Spectrin, KIAA0302, Spectrin beta Chain Brain 2, Spectrin beta Non-erythrocytic 2, Spectrin Non-erythroid beta Chain 2, SPTBN2, Spinocerebellar Ataxia 5, SCA5, SCA 5)
Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).
Applications
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
The epitope recognized by this antibody maps to a C-terminal region between residue 2300 and 2390 of human spectrin, beta, non-erythrocytic 2 (spinocerebellar ataxia 5). Species sequence homology (100%): mouse and rat
Form
Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7-8.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human spectrin, beta 3.
