Technical Data

S6505-02E
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E WB
Crossreactivity
Hu
Accession #
NP_003734
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-SRC1, NT (Nuclear Receptor Coactivator 1, NCoA-1, Steroid Receptor Coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal Carcinoma Antigen NY-REN-52, Class E Basic Helix-loop-helix Protein 74, bHLHe74, NCOA1)

SRC1 acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. This protein binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the N-terminal region of human SRC1 (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human SRC1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Lavery,D.N.,Biochemistry 47(11), 3352-3359 (2008). 2. Wang,S., J. Biol. Chem. 282(5), 2765-2775 (2007).
USBio References
No references available
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