Goat Anti-Stabilin 1 (Stabilin-1, Fasciclin, EGF-like, Laminin-type EGF-like and Link Domain-containing Scavenger Receptor 1, FEEL-1, MS-1 Antigen, FEEL1, KIAA0246)
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
Applications
Suitable for use in ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilutions
Peptide ELISA: 1:8000 Immunohistochemistry: 3-5ug/ml shows endothelial staining in paraffin embedded human spleen Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-DFPDTQRILTVK, from the C-terminal of human Stabilin 1. Species Sequence Homology: bovine, canine and porcine
Form
Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human Stabilin 1.
