Technical Data

T0291-91E
Clone Type
Polyclonal
Host
Goat
Source
Human
Isotype
IgG
Grade
Affinity Purified
Applications
E
Crossreactivity
Hu Mo
Accession #
NP_690000.2
Gene ID
257397, 66724
Shipping Temp
Blue Ice
Storage Temp
-20°C
Goat Anti-TAB3 (TGF-beta-activated Kinase 1 and MAP3K7-binding Protein 3, TGF-beta-activated Kinase 1-binding Protein 3, TAK1-binding Protein 3, TAB-3, Mitogen-activated Protein Kinase Kinase Kinase 7-interacting Protein 3, MAP3K7IP3, NF-kappa-B-activating Protein 1, NAP1)

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Applications
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution
ELISA: 1:32,000 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to C-HSPDDNRMNRN, from MAP3K7IP3, at the internal region of the protein (NP_690000.2).
Form
Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes MAP3K7IP3. Species sequence homology: Human and mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Lu M, Lin SC, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H. XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell. 2007 Jun 8;26(5):689-702.
USBio References
No references available
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