T2040-06FX
Clone Type
MonoclonalHost
HamsterSource
MouseIsotype
IgGClone Number
5K24Grade
PurifiedApplications
FC IPCrossreactivity
MoShipping Temp
Blue IceStorage Temp
4°C Do Not FreezeNotes
Preservative Free
Hamster Anti-TCR, gamma, delta (T Cell Receptor) (Azide Free)
The TCR gamma, delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains.1 It is expressed during thymopoiesis and on the small subpopulation of gamma, delta TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma, delta+ and have limited receptor diversity.1, 2 The TCR gamma, delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation.3
Applications
Suitable for use in Immunoprecipitation and Flow Cytometry. Other applications have not been tested.
Recommended Dilution
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C. For long-term storage, aliquot and store at 4°C. Do not freeze. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Mouse TCR, gamma, delta.
Form
Supplied as a liquid in PBS. No preservative added.
Specificity
Recognizes gamma/delta T-cell receptor (TCR) complex. Specific for the gamma, delta heterodimer and plate-bound antibody activates gamma, delta TCR-bearing cells. Does not react with alpha, beta TCR-expressing T cells.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Davis, M.M. Annu. Rev. Biochem. 59:475(1990). 2. Allison, J.P., and W.L. Havran. Annu. Rev. Immunol. 9:679(1991) 3. Klausner, R.D., and L.E. Samuelson. Cell 64:875.(1991) 4. Dent, A.L., et al. Nature 343:714(1990). 5. Bluestone, J.A., et al. Immunol. Rev. 120:5 (1991) 6. Houlden, B.A., et al. Cold Spring Harbor Symp. Quant. Biol. 54:45.(1989) 7. Barrett, T.A., et al. Immunol. Res. 10:341.(1991)USBio References
No references available