Rabbit Anti-TREK1 (Twik-Related Potassium Channel 1, Kcnk2)
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended Dilutions
Western Blot: 2ug/ml. Esssential to run against membrane preps. Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide corresponding to aa1-100 from the N-terminal region of human TREK1 (Swiss-Prot# Q9NRT2).
Form
Supplied as a liquid in PBS, 0.05% sodium azide
Purity
Purified by affinity chromatography
Specificity
Recognizes human TREK 1. Species Seqeuence Homology: mouse, bovine; 100%, rat; 88%
