Technical Data

Y2058
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Isotype
IgG
Grade
Purified
Applications
E IHC WB
Crossreactivity
Hu Mo
Shipping Temp
Blue Ice
Storage Temp
-20°C
Rabbit Anti-YES, NT (Proto-oncogene tyrosine-protein kinase YES, p61-YES, C-YES)

YES is a member of the Src family of non-receptor tyrosine kinases participating in a wide range of cellular signalling pathways The gene that encodes YES is the cellular homolog of the Yamaguchi sarcoma virus oncogene. This gene lies in proximity to thymidylate synthase gene on chromosome 18, and a pseudogene of it has mapped to chromosome 22

Applications
Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested.
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100 Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Immunogen
Synthetic peptide selected from the N-terminal region of human YES (KLH).
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by ammonium sulfate precipitation
Specificity
Recognizes human YES. Species Crossreactivity: mouse.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1.Oh, H.S., et al., J. Biol. Chem. 277(39):36489-36498 (2002). 2.Leclerc, P., et al., Biol. Reprod. 67(1):301-307 (2002). 3.Silverman, G.A., et al., Genomics 15(2):442-445 (1993). 4.Brickell, P.M., Crit Rev Oncog 3(4):401-446 (1992). 5.Sukegawa, J., et al., Mol. Cell. Biol. 7(1):41-47 (1987).
USBio References
No references available
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