Technical Data

001101
CAS Number
29769-49-1
Grade
Highly Purified
MDL Number
MFCD16251155
Molecular Formula
C9H7N5O3
Molecular Weight
233.18
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
2-Acetamido-6-formylpteridin-4-one
N-(6-Formyl-3,4-dihydro-4-oxo-2-pteridinyl)acetamide; 2-Acetamido-4-hydroxy-6-pteridinecarboxaldehyde; NSC 129965; Ac-6-FP

Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation.1 It dose-dependently increases the surface expression of MHC-related 1 (Mr1) in WT3 cells overexpressing Mr1 (WT3-m) following incubation with E. coli but does not activate MAIT cells cocultured with WT3-m cells when used at concentrations ranging from 0.23-15uM. Acetyl-6-formylpterin is also a degradation product of folic acid and a precursor in the synthesis of 2’-hydroxy-7,8-dihydrofolate, which is a metabolite of para-aminosalicylic acid (PAS) in M. tuberculosis.2

Synonyms
N-(6-Formyl-3,4-dihydro-4-oxo-2-pteridinyl)acetamide; 2-Acetamido-4-hydroxy-6-pteridinecarboxaldehyde; NSC 129965
CAS Number
29769-49-1
Molecular Formula
C9H7N5O3
Molecular Weight
233.18
Purity
≥95%
Appearance
Crystalline solid
Solubility
Soluble in DMF at 50mg/ml, Ethanol at 1mg/ml, PBS, pH 7.2 at 0.1mg/ml
Storage and Stability
Lyophilized product is stable for 6 months after receipt at -20°C. Keep Under Inert Atmosphere. Reconstitute with sterile PBS. Stable for 24 hours.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Soudais, C., Samassa, F., Sarkis, M., et al. In vitro and in vivo analysis of the gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells. J. Immunol. 194(10), 4641-4649 (2015). 2. Dawadi, S., Kordus, S.L., Baughn, A.D., et al. Synthesis and analysis of bacterial folate metabolism intermediates and antifolates. Org. Lett. 19(19), 5220-5223 (2017). 3. Freisleben, A., et al.: J. Agric. Food Chem., 50, 4760 (2002)
USBio References
No references available
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