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001521 N-Acetylpiperazine-N’-(4-phenol) Ketoconazole CAS: 1346598-39-7

Specifications
CAS Number
1346598-39-7
Grade
Highly Purified
Molecular Formula
C38H42Cl2N6O6
Molecular Weight
749.68
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
1-(4-{3-[4-(4-Acetylpiperazin-1-yl)phenoxy]-4-[2-(2,4-dichlorophenyl)-2-imidazol-1-ylmethyl[1,3]dioxolan-4-ylmethyl]phenyl}piperazin-1-yl)ethanone; Ketoconazole Impurity B

N-Acetylpiperazine-N-(4-phenol) ketoconazole is an analog inhibitor that has been shown to inhibit the activity of several kinases. This compound has been tested against a variety of cancer cells and has demonstrated potent anticancer activity, inducing apoptosis in Chinese hamster ovary cells. N-Acetylpiperazine-N-(4-phenol) ketoconazole also inhibits the activity of dapoxetine, a drug used to treat premature ejaculation. In addition to its anticancer properties, this compound has shown promise as an anti-inflammatory agent due to its ability to inhibit the production of prostaglandins. This inhibitor can be detected in urine and may have potential therapeutic applications in the treatment of various cancers.

Synonyms
1-(4-{3-[4-(4-Acetylpiperazin-1-yl)phenoxy]-4-[2-(2,4-dichlorophenyl)-2-imidazol-1-ylmethyl[1,3]dioxolan-4-ylmethyl]phenyl}piperazin-1-yl)ethanone; Ketoconazole Impurity B
CAS No
1346598-39-7
Molecular Formula
C38H42Cl2N6O6
Molecular Weight
749.68
Appearance
White to off-white solid
Purity
≥95% (HPLC)
NMR, MS
Conforms to reference
Elemental Analysis
%C: 59.34, %H: 5.63, %N: 10.97
Solubility
Chloroform (Very Slightly), DMSO (Slightly), Methanol (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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