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001673 S-(5'-Adenosyl)-L-Methionine Disulfate CAS:

Specifications
References
Grade
Highly Purified
Molecular Formula
C15H26N6O13S
Molecular Weight
594.59
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Disulfate; 5'-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Disulfate; S-Adenosylmethionine Disulfate; Active Methionine Disulfate; Ademetionine Disulfate; L-S-Adenosylmethionin Disulfate; S-Adenosyl-L-methionine Disulfate

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Synonyms
5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Disulfate; 5'-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Disulfate; S-Adenosylmethionine Disulfate; Active Methionine Disulfate; Ademetionine Disulfate; L-S-Adenosylmethionin Disulfate; S-Adenosyl-L-methionine Disulfate
CAS No
Free Acid: 979-92-0 Chloride: 24346-00-7
Molecular Formula
C15H26N6O13S
Molecular Weight
594.59
Appearance
Off-white to light brown solid
Purity
≥95%
Melting Point
>103°C (subl.)
TLC Conditions
C18; Methanol : Water : Acetic Acid = 5 : 5 : 0.1; Visualized with UV and KMnO4; Single Spot, Rf = 0.40
Elemental Analysis (Theoretical)
%C: 30.30, %H: 4.41, %N: 14.13
Solubility
Methanol (Very Slightly, Heated), Water (Slightly)
Storage and Stability
Store at -20°C. Hygroscopic. Under Inert Atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Friedel, H., et al.: Drugs, 38, 389 (1989), Lu, S., et al.: Int. J. Biochem. Cell Biol., 32, 391 (2000), Amin, K., et al.: Pharm. Res., 18, 914 (2001)
USBio References
No references available
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