S-(5'-Adenosyl)-L-Methionine-d3 Disulfate Salt (Mixture of Diastereomers)
5’-[[(3S)-3-Amino-3-carboxypropyl](methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; 5’-[(L-3-Amino-3-carboxypropyl)(methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; S-Adenosylmethionine-d3 Disulfate; Active Methionine-d3 Disulfate; Ademetionine-d3 Disulfate; L-S-Adenosylmethionin-d3 Disulfate; S-Adenosyl-L-methionine-d3 Disulfate
Labeled S-(5’-Adenosyl)-L-methionine. Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Synonyms
5’-[[(3S)-3-Amino-3-carboxypropyl](methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; 5’-[(L-3-Amino-3-carboxypropyl)(methyl-d3)sulfonio]-5’-deoxyadenosine Disulfate; S-Adenosylmethionine-d3 Disulfate; Active Methionine-d3 Disulfate; Ademetionine-d3 Disulfate; L-S-Adenosylmethionin-d3 Disulfate; S-Adenosyl-L-methionine-d3 Disulfate
Molecular Formula
C₁₅H₂₃D₃N₆O₁₃S₃
Appearance
White to pale yellow solid
Purity
≥95% Chemical, ≥98% Isotopic
Melting Point
>102°C (dec.)
Solubility
Water (Slightly)
Method for Determining Identity
Proton NMR spectroscopic analysis and Mass spectrometric analysis
TLC Conditions
C18; Methanol: Water: Acetic Acid=5:5:0.02; Visualized with UV and KMnO4; Rf=0.40
Elemental Analysis
Calculated: %C: 30.15, %H: 4.39, %N: 14.06
Normalized Intensity
As Reported
Sulfate Content (Ion Chromatography)
~33%
Water Content (Elemental Analysis)
~3%
Storage and Stability
Store at -20°C under an atmosphere of inert gas. Stable for 6 months after receipt. Caution: Hygroscopic.
