002892
CAS Number
1236699-92-5Grade
Highly PurifiedMolecular Formula
C15H15FIN3O3Molecular Weight
431.2EU Commodity Code
38220090Shipping Temp
RTStorage Temp
RTAS-703026
N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor, in human multiple myeloma (MM). AS703026 induces pleiotropic anti-myeloma activity in vitro and in vivo. MEK inhibitors are useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Billadeau, D., et al.: Cancer Res., 55, 3640 (1995), Kolch, W., et al.: Biochem. J., 351, 289 (2000), Smith, M., et al.: Leukemia, 17, 274 (2003), Adjei, A., et al.: J. Clin. Oncol., 26, 2139 (2008),USBio References
No references available