2,3-Butadione; 2,3-Diketobutane; 2,3-Dioxobutane; Biacetyl; Butanedione; Diacetyl; Dimethyl Diketone; Dimethylglyoxal; NSC 8750; DA;

2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.