Calcitriol (Vitamin D3)
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1α,3β,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol,; 1α,25-Dihydroxycholecalciferol; 1α,25-Dihydroxyvitamin D3; Calcijex; Dihydroxyvitamin D3; Panbonis; Ro 21-5535; Rocaltrol; Silkis; Solbone P; Soltriol; Topitriol; Toptriol
The biologically active form of Vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic.
Synonyms
(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol; (1α,3β,5Z,7E)- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol,; 1α,25-Dihydroxycholecalciferol; 1α,25-Dihydroxyvitamin D3; Calcijex; Dihydroxyvitamin D3; Panbonis; Ro 21-5535; Rocaltrol; Silkis; Solbone P; Soltriol; Topitriol; Toptriol
Molecular Formula
C₂₇H₄₄O₃
Appearance
Supplied as a white solid
Melting Point
>94ºC (dec)
Solubility
Chloroform (Slightly), Methanol (Slightly)
Method for Determining Identity
Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol=9:1; Visualized with UV and AMCS; Single Spot, Rf=0.40
Elemental Analysis
Calculated: %C: 77.83; %H: 10.64
Water Content (Karl Fischer)
As Reported
Specific Rotation (c=0.1, Methanol)
As Reported
Storage and Stability
Long-term storage is recommended at -70°C under Inert gas. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Air and temperature sensitive. Store under Inert atmophere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
Supplied as a white solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
