Cercosporamide

005964

CAS Number

131436-22-1

Grade

Highly Purified

Molecular Formula

C16H13NO7

Molecular Weight

331.28

EU Commodity Code

38220090

Shipping Temp

Storage Temp

(9aS)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide;|(S)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide; (-)-Cercosporamide;

Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3. Cercosporamide effectively inhibits eIF4E phosphorylation as well as inibitiing inhibits Pkc1. Cercosporamide displays antiproliferative and proapoptotic activity in cancer cells in vitro.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Sussman, A. et al.: Eukaryot. Cell, 3, 932 (2004); Konicek, B.W. et al.: Cancer Res., 71, 1849 (2011); Hou, J. et al.: Oncotarget, 3, 118 (2012);

USBio References

No references available

Technical Data