Technical Data

006830
CAS Number
113852-37-2
Grade
Highly Purified
Molecular Formula
C8H14N3O6P•xH2O
Molecular Weight
279.19
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Cidofovir Hydrate
[[(1S)-2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid Hydrate; 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine Hydrate; (S)-[[2-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic Acid Hydrate; (S)-1-(3-hydroxy-2-phosphonomethoxypropyl)cytosine Hydrate; (S)-HPMPC Hydrate; Cidovir Hydrate; GS 0504 Hydrate; Vistide Hydrate;

An injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. It is used in the treatment of acyclovir resistant herpes as well as a complementary intralesional therapy against papillomatosis caused by human papillomavirus (HPV).

Form
White Solid
Melting Point
256-260°C (dec.)
Solubility
DMSO (Sparingly), Water (Sparingly)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Rahal, F.M. et al.: Ann. Internal Med., 125, 98 (1996); Johnson, J.A. et al.: Antimicrob. Agents Chemother., 43, 1190 (1999); Ho, H.T. et al.: Mol. Pharmacol., 41, 197 (1992);
USBio References
No references available
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