Technical Data

006833
CAS Number
302803-72-1
Grade
Highly Purified
Molecular Formula
C17H9Cl2N3O2
Molecular Weight
358.18
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
Ciliobrevin A
2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile; HPI-4; |

Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Heald, R., et al.: Nature, 382, 420 (1996), Gaglio, T., et al.: J. Cell Biol., 138, 1055 (1997), Zhu, G., et al.: J. Med. Chem., 49, 2063 (2006), Varma, D., et al.: J. Cell Biol., 182, 1045 (2008),
USBio References
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