006833
CAS Number
302803-72-1Grade
Highly PurifiedMolecular Formula
C17H9Cl2N3O2Molecular Weight
358.18EU Commodity Code
38220090Shipping Temp
RTStorage Temp
RTCiliobrevin A
2,4-Dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile; HPI-4; |
Ciliobrevin A is a Hedgehog pathway inhibitor; ciliogenesis inhibitor. The Hedgehog (HH) signaling pathway is targeted for anti-cancer therapeutics. Ciliobrevin A inhibited proliferation of cerebellar granula neuron precursor cells, an important model of HH signaling.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Heald, R., et al.: Nature, 382, 420 (1996), Gaglio, T., et al.: J. Cell Biol., 138, 1055 (1997), Zhu, G., et al.: J. Med. Chem., 49, 2063 (2006), Varma, D., et al.: J. Cell Biol., 182, 1045 (2008),USBio References
No references available