007049
CAS Number
53-06-5Grade
Highly PurifiedMDL Number
MFCD00003610Molecular Formula
C21H28O5Molecular Weight
360.44EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CCortisone
4-Pregnene-17α,21-diol-3,11,20-trione; 17,21-Dihydroxy-pregn-4-ene-3,11,20-trione; 17-Hydroxy-11-dehydrocorticosterone; 17a-Hydroxy-11-dehydrocorticosterone; 11-Dehydro-17-hydroxycorticosterone;|Adrenalex; Compound E; Cortisate; Cortivite; Cortogen; Cortone; NSC 9703; Kendall’s Compound E; Reichstein’s Substance Fa
Cortisone is a steroid hormone that belongs to the group of glucocorticoids. It is used in the treatment of inflammatory conditions, such as infectious diseases and asthma. Cortisone has been shown to have anti-inflammatory effects and can be used for the treatment of these conditions. Cortisone inhibits adipose tissue development by suppressing the expression of lipogenic enzymes and genes, which are involved in lipid synthesis. Cortisone has also been shown to have potential as a biomarker for identification of inflammation and infection, with higher levels found in patients with active inflammation or infection.
Synonyms
4-Pregnene-17α,21-diol-3,11,20-trione; 17,21-Dihydroxy-pregn-4-ene-3,11,20-trione; 17-Hydroxy-11-dehydrocorticosterone; 17a-Hydroxy-11-dehydrocorticosterone; 11-Dehydro-17-hydroxycorticosterone; Adrenalex; Compound E; Cortisate; Cortivite; Cortogen; Cortone; NSC 9703; Kendall’s Compound E; Reichstein’s Substance Fa
Molecular Formula
C21H28O5
Appearance
White to off-white powder
Melting Point
223-228°C (dec.) (lit.)
Solubility
Acetone, DMSO, Ethanol, Methanol, Chloroform: Methanol (1:1): 50mg/ml
Solubility
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Honda, A., et al.: J. Biol. Chem., 268, 7759 (1993), Narko, K., et al.: J. Clin. Endocrinol. Metab., 86, 1765 (2001), Michael, A., et al.: Reproduction, 126, 425 (2003),USBio References
No references available