007819
CAS Number
67035-22-7Grade
Highly PurifiedMolecular Formula
C₁₇H₁₆N₂O₆Molecular Weight
344.32EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CDehydro Nifedipine (Nifedipine EP Impurity A)
2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester;|Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate; BAY-b 4759; Nifedipine EP Impurity A
Dehydro nifedipine is an active metabolite of nifedipine, a calcium channel blocker present in formulations used to treat hypertension and angina. Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.2 Dehydro nifedipine inhibits glucose uptake in PC-12 cells.
Synonyms
2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-Dimethyl Ester; Dimethyl 2,6-Dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate; BAY-b 4759; Nifedipine EP Impurity A9
Molecular Formula
C₁₇H₁₆N₂O₆
Appearance
Pale yellow solid
Melting Point
As reported
Solubility
Soluble in ethanol, DMF or DMSO. Poor water solubility. Make freshly daily.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Ardizzone, T.D., Lu, X.H., and Dwyer, D.S. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists. Am. J. Physiol. Cell Physiol. 283(2),:C579-586 (2002). 2. Patki, K.C., Von Moltke, L.L., and Greenblatt, D.J. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab. Dispos. 31(7):938-944 (2003). 3. Ago, T., Yang, Y., Zhai, P., et al. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J. Cardiovasc. Transl. Res. 3(4):304-313 (2010). 4. Lemay, J., Tea, B.S., Hamet, P., et al. Regression of neointimal lesions in the carotid artery of nifedipine-treated SHR and WKY rats: Possible role of apoptosis. J. Vasc. Res. 38(5):462-470 (2001). 5. Guengerich, F., et al.: J. Biol. Chem., 261:5051USBio References
No references available